Predictive models to counter the spread of the COVID-19 pandemic

22/12/2020 The working group led by epidemiologist Stefano Merler has been involved in national and regional government Task Forces (Lombardy, Veneto, Trentino) set up to respond to the Coronavirus emergency through transmissibility mathematical models.

The work of the research group focused on the production of dozens of alternative scenarios based on which decision-makers have made their choices.

The high level of the scientific results achieved can be seen from the journals that hosted the analysis conducted (SCIENCE, THE LANCET INFECTIOUS DISEASES, EUROSURVEILLANCE, JAMA).

In particular, the studies covered three geographical areas to which specific insights were dedicated: the Lombardy region, the most acute case on the national territory, Italy and China.

Among the aspects considered were the effectiveness of the restrictive measures adopted in Italy, the effects of travel restrictions from China on the spread of the virus in the world and the probability of developing symptoms following the infection of SARS-CoV-2.


Flavia Riccardo, Marco Ajelli, Xanthi D Andrianou1, Antonino Bella, Martina Del Manso, Massimo Fabiani, Stefania Bellino, Stefano Boros, Alberto Mateo Urdiales, Valentina Marziano, Maria Cristina Rota, Antonietta Filia, Fortunato D’Ancona, Andrea Siddu, Ornella Punzo, Filippo Trentini, Giorgio Guzzetta, Piero Poletti, Paola Stefanelli, Maria Rita Castrucci, Alessandra Ciervo, Corrado Di Benedetto, Marco Tallon, Andrea Piccioli, Silvio Brusaferro, Giovanni Rezza, Stefano Merler, Patrizio Pezzotti, the COVID-19 working group

Epidemiological characteristics of COVID-19 cases and estimates of the reproductive numbers 1 month into the epidemic, Italy, 28 January to 31 March 2020 in EUROSURVEILLANCE, Volume 25, issue 49

Paola Stefanelli; Antonino Bella; Giorgio Fedele; Serena Pancheri; Pasqualina Leone; Paola Vacca; Arianna Neri; Anna Carannante; Cecilia Fazio; Eleonora Benedetti; Stefano Fiore; Concetta Fabiani; Maurizio Simmaco; Iolanda Santino; Maria Grazia Zuccali,; Giancarlo Bizzarri; Rosa Magnoni; Pier Paolo Benetollo; Stefano Merler; Silvio Brusaferro; Giovanni Rezza; Antonio Ferro
Prevalence of SARS-CoV-2 IgG antibodies in an area of North-eastern Italy with a high incidence of COVID-19 cases: a population-based study, in “ScienceDirect” Volume 26 Issue 11

Chinazzi, Matteo; Davis, Jessica T; Ajelli, Marco; Gioannini, Corrado; Litvinova, Maria; Merler, Stefano; Pastore Y Piontti, Ana; Mu, Kunpeng; Rossi, Luca; Sun, Kaiyuan; Viboud, Cécile; Xiong, Xinyue; Yu, Hongjie; Halloran, M Elizabeth; Longini, Ira M; Vespignani, Alessandro, The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak, in «SCIENCE», vol. 368, n. 6489, 2020, pp. 395 -400

Zhang, Juanjuan; Litvinova, Maria; Liang, Yuxia; Wang, Yan; Wang, Wei; Zhao, Shanlu; Wu, Qianhui; Merler, Stefano; Viboud, Cécile; Vespignani, Alessandro; Ajelli, Marco; Yu, Hongjie, Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China, in «SCIENCE», 2020, pp. eabb8001

Grasselli, Giacomo; Zangrillo, Alberto; Zanella, Alberto; Antonelli, Massimo; Cabrini, Luca; Castelli, Antonio; Cereda, Danilo; Coluccello, Antonio; Foti, Giuseppe; Fumagalli, Roberto; Iotti, Giorgio; Latronico, Nicola; Lorini, Luca; Merler, Stefano; Natalini, Giuseppe; Piatti, Alessandra; Ranieri, Marco Vito; Scandroglio, Anna Mara; Storti, Enrico; Cecconi, Maurizio; Pesenti, Antonio, Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy, in «JAMA», 2020

Zhang, Juanjuan; Litvinova, Maria; Wang, Wei; Wang, Yan; Deng, Xiaowei; Chen, Xinghui; Li, Mei; Zheng, Wen; Yi, Lan; Chen, Xinhua; Wu, Qianhui; Liang, Yuxia; Wang, Xiling; Yang, Juan; Sun, Kaiyuan; Longini, Ira M; Halloran, M Elizabeth; Wu, Peng; Cowling, Benjamin J; Merler, Stefano; Viboud, Cecile; Vespignani, Alessandro; Ajelli, Marco; Yu, Hongjie, Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study, in «THE LANCET INFECTIOUS DISEASES», 2020

Guzzetta, Giorgio; Poletti, Piero; Ajelli, Marco; Trentini, Filippo; Marziano, Valentina; Cereda, Danilo; Tirani, Marcello; Diurno, Giulio; Bodina, Annalisa; Barone, Antonio; Crottogini, Lucia; Gramegna, Maria; Melegaro, Alessia; Merler, Stefano, Potential short-term outcome of an uncontrolled COVID-19 epidemic in Lombardy, Italy, February to March 2020, in «EUROSURVEILLANCE», vol. 25, n. 12, 2020

Aleta, Alberto; Martín-Corral, David; Pastore y Piontti, Ana; Ajelli, Marco; Litvinova, Maria; Chinazzi, Matteo; Dean, Natalie E.; Halloran, M. Elizabeth; Longini Jr, Ira M.; Merler, Stefano; Pentland, Alex; Vespignani, Alessandro; Moro, Esteban; Moreno, Yamir. Modelling the impact of testing, contact tracing and household quarantine on second waves of COVID-19  in «NATURE HUMAN BEHAVIOUR», vol.4, 2020

Deng, Xiaowei; Yang, Juan; Wang, Wei; Wang, Xiling; Zhou, Jiaxin; Chen, Zhiyuan; Li, Jing; Chen, Yinzi; Yan, Han; Zhang, Juanjuan; Zhang, Yongli; Wang, Yan; Qiu, Qi; Gong, Hui; Wei, Xianglin; Wang, Lili; Sun, Kaiyuan; Wu, Peng; Ajelli, Marco; Cowling, Benjamin J; Viboud, Cecile; Yu, Hongjie  Case fatality risk of the first pandemic wave of novel coronavirus disease 2019 (COVID-19) in China in «CLINICAL INFECTIOUS DISEASES», 2020

The researches are co-financed by Fondazione VRT (Fondazione per la Valorizzazione della Ricerca Trentina).